DO YOU WANT MORE ENERGY?
While vitamin B12 tends to get the spotlight, vitamin B3 is often overlooked. It is a nutrient critical for proper mitochondrial energy production and basic metabolic processes. If it is contained in a multi-vitamin, it is under-dosed while other nutrients best acquired from food are over-dosed.
If one is talking vitamin B3, it is usually a harmful form called niacin to induce a "flush". Usually niacin is combined with far infrared sauna sweating and rebounding on a trampoline. This is supposed to be anti-aging. Unfortunately this is very detrimental to health. There is a huge release of serotonin (a stress hormone) and prostaglandin D2 (an inflammatory marker) when high dose niacin (flushing or non-flushing) is ingested (Papaliodis, et al, 2008). This is an extreme stress to the body and will lower the metabolic rate.
A much safer alternative to niacin is niacinamide, sometimes referred to as nicotinamide. Niacinamide is a precursor of nicotinamide adenine dinucleotide (NAD+) and is involved in a multitude of intra- and inter-cellular processes, which regulate some of the cell's metabolic, stress, and immune responses to physiological or pathological signals.
Niacinamide is readily converted into the active forms of niacin: NAD+, NADH and NADPH, which are co-factors in cellular energy production, help to maintain DNA stability, and allow over 200 enzymatic reactions to take place.
NAD stands for nicotinamide adenine dinucleotide, which is a key enzyme that allows the production of adenosine triphosphate, or ATP, cellular energy. Niaacinamide has been investigated for potential neuroprotective effects in cellular, animal, and human studies (Rennie, et al., 2015).
- Increases mitochondrial energy production*
- Reduces pigmentation, wrinkles and sebum production
- Acts as an antioxidant
- Suppresses SIRT2 gene, which may extend lifespan*
- Protects against ultraviolet-induced skin damage and immune suppression*
- Suppresses the SIRT1 gene* (Ref)
- Inhibits the release of free fatty acids* (Ref) (which may improve glucose utilization*)
- Decreases prostaglandin synthesis* (Ref)
- Inhibits nitric oxide*
- Reduces serotonin synthesis*
- Protects the pancreas, nerves, vascular cells*
- Increases metabolic rate*
Niacinamide is an anti-inflammatory vitamin that has proven to be beneficial for conditions such as acne, rosacea, dermatitis, skin photo-aging, age-related cognitive decline, Alzheimer's disease, Parkinson's disease, and for ischaemic and traumatic brain injury. If the foundation of an animal-based diet/nutrition is in place, then supplementing the right form of vitamin B3 may help to decrease fatigue and support mitochondrial ATP production.*
WHERE DO PUFA'S FIT IN?
Polyunsaturated fats (either ingested or stored in your tissues from decades of consuming omega-3 supplements and seed oils) increase estrogen, a stress hormone.
Estrogen contributes to the formation of many different diseases, including liver disease, thyroid disease, infertility, obesity, osteoporosis, neurodegeneration, breast cancer and prostate cancer. The more estrogen you have the faster you age. Its main function is to inhibit cellular respiration, lowering oxygen utilization, decreasing energy production and causing necrosis (cell death).
PUFAs (polyunsaturated fats), especially omega-3 DHA, push the conversion of the amino acid l-tryptophan to quinolinic acid (pyridine dicarboxylic acid) instead of pyridine carboxylic acid (vitamin B3).
By supplementing niacinamide you can counter the negative downstream effects that are caused by PUFAs - decreased cellular function, increased estrogen, decreased redox potential.*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.
I’ve barely been on this for a few weeks and I see a noticeable difference in the skin on my whole body. I live in south Florida so sunburn/Iv damage is a constant but this is definitely making a difference in my skins ability to be in the sun as well as my face as well!
Excellent product, non flushing, easily tolerated. I take a wide range of vitamins but I have noticed an uptick in sustainable energy, not sure if it's NAD or what but I'm going to keep it up.
Started taking vitamin E and Vitamin B3 a week ago. Haven’t noticed anything yet. But my doctor said take both for better skin and UV protection.
I showed my chiropractor father this product and he said I should've never spent $40 on a product like this because it shouldn't be that expensive. I looked up the prices of niacinimide on other websites, vitacost for example and they sold it anywhere from $2-$6 for a 100-200 count. I would say to try other places first before you spend $40. I like Mitolife's other products A LOT, but I feel a little duped by this one. I've been taking this for a couple weeks now and I have noticed some more energy but not worth the price for a college kid.
Still I am not sure when I started I have headqe and not good sleep but I less the dose I open the tablet and I take little powder mix it with water so I feel better and I think its improving my skin as well