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43 total reviews

Regular price $30.00USD
Regular price Sale price $30.00USD


While vitamin B12 tends to get the spotlight, vitamin B3 is often overlooked. It is a nutrient critical for proper mitochondrial energy production and basic metabolic processes. If it is contained in a multivitamin, it is under-dosed while other nutrients best acquired from food are overdosed. 

Niacinamide is a precursor of nicotinamide adenine dinucleotide (NAD+) and is involved in a multitude of intra- and inter-cellular processes, which regulate some of the cell's metabolic, stress, and immune responses to physiological or pathological signals.

Niacinamide is readily converted into the active forms of niacin: NAD+, NADH and NADPH, which are co-factors in cellular energy production, help to maintain DNA stability, and allow over 200 enzymatic reactions to take place.

Once niacinamide is converted into NAD+ it acts as the buffer for cells to regulate the aging process. NAD+ levels tend to drop with age and consistently decline. When we are young, our cells have an abundance of NAD+. 

NAD+ regulation by supplementing with niacinamide is known to be a key compound in the anti-aging research arena. David Sinclair, the scientist most people think of when it relates to aging, uses another form of niacinamide known as NMN to support this. Inevitably NMN does the same thing as niacinamide, but it is more marketable for his research. 

NAD stands for nicotinamide adenine dinucleotide, which is a key enzyme that allows the production of adenosine triphosphate, or ATP, cellular energy. Niacinamide has been investigated for potential neuroprotective effects in cellular, animal, and human studies (Rennie, et al., 2015). 


  • Increases mitochondrial energy production 
  • Neuroprotective
  • Reduces pigmentation, wrinkles and sebum production
  • Acts as an antioxidant
  • Suppresses SIRT2 gene, which may extend lifespan 
  • Protects against ultraviolet-induced skin damage and immune suppression
  • Suppresses the SIRT1 gene (Ref)
  • Inhibits the release of free fatty acids (Ref) (which may improve glucose utilization)
  • Decreases prostaglandin synthesis (Ref)
  • Inhibits nitric oxide
  • Reduces serotonin synthesis
  • Protects the pancreas, nerves, vascular cells
  • Increases metabolic rate

Niacinamide is an anti-inflammatory vitamin that has proven to be beneficial for conditions such as acne, rosacea, dermatitis, skin photo-aging, age-related cognitive decline, Alzheimer's disease, Parkinson's disease, and for ischaemic and traumatic brain injury. If the foundation of balanced nutrition is in place (no diets), then supplementing the right form of vitamin B3 may help to decrease fatigue and support mitochondrial ATP production.


NAD+ and Vitamin B3: From Metabolism to Therapies

Nicotinamide and neurocognitive function

Niacin-induced "flush" involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model

Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin

Nicotinamide restores cognition in Alzheimer's disease transgenic mice

Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia

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Customer Reviews

Based on 43 reviews
Alex Woodhouse (Vancouver, CA)
Always good

Very cost effective, good for long term health and to help other collagen products.

Vincent Cannistraro (Keene, US)
NAD POWER- The name applies

NAD Power seems to apply. I am noticing an efficiency factor, speeds up bowel movement, mental clarity and other private factors. Enjoying and staying with it…..

Myra Gazvoda (Denver, US)

Love mitolifes attention to all the best ingredients!

I Bevie (Denver, US)

I had been taking Niacinamide for already a year on the advice of my dermatologist , I had just pick out one from one of my supplement companies in the dose she recommended, 180 mg made by Thorne, I think. Never noticed any anything. Tried Nad Power, same 180mg , still haven’t notice anything different, not sure if Nad is a different process of extracting Vit B3 or what but it is $12 more expensive /bottle. Maybe someone can explain to me why it’s better. Still gave it a 5 because no bad effects. I don’t think it’s meant to be used instead of using a sunscreen tho, that seems kinda risky.

Limmons (Boardman, US)
No sunblock/no sunburn

I have been taking one or two of these per day. I just returned from Mexico. I decided to not wear sunscreen on this trip, practicing safe sun exposure instead. I did not burn after one week. Incidentally, I take Shilajit, K2, C, Dissolve It All and Oyster extract from Mitolife as well. Amazing stuff. Thank youuuuuuu, Matt!