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MELATONIN - MITOCHONDRIAL SUPPORT

MELATONIN - MITOCHONDRIAL SUPPORT

7 total reviews

Regular price $10.00
Regular price $20.00 Sale price $10.00
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ABOUT

Melatonin is one of the most misunderstood miracle compounds. Often called "the sleep hormone" it is lumped in with quick fixes and hormone therapy.

The reality is that melatonin is a master antioxidant and its beneficial effects extend far beyond sleep improvement. Before we dive into the details lets bust three myths that we often hear about melatonin.

Myth 1: Melatonin is mostly secreted by our pineal gland.

Actually, melatonin production by the pineal gland only accounts for 5% of total melatonin production. The majority, 95%, is produced by mitochondria in every cell throughout our body and is not regulated by dark-light circadian rhythm cycles.

Myth 2: Supplementing exogenous melatonin will lower our endogenous production.

The truth is the exact opposite. Taking exogenous melatonin has been shown to increase endogenous production. It does this by reactivating the pyruvate dehydrogenase complex to produce the necessary substrate acetyl Co-A for melatonin synthesis.

Myth 3: Melatonin is mostly a sleep hormone that regulates our circadian rhythm.

While melatonin does help regulate our circadian rhythm, it also scavenges free radicals, increases ATP production in the mitochondria, regulates glucose metabolism in every cell, regulates insulin secretion, maintains optimal mitochondria membrane potentials, modulates the immune system, and has an overall anti-aging effect on the body.

By 15–20 years of age we experience, on average, an 80% decline in melatonin levels and that decline continues into old age (Waldhauser, et al 1988). When we add to this bright light at night and electromagnetic radiation (EMR), we have a recipe for the lowest melatonin levels in human history. Could there be a connection to increased rates of disease?

What we're really talking about is mitochondrial integrity. Melatonin levels in mitochondria are about 100× higher than the levels found in the blood (Beaupre, et al 2021). Without sufficient melatonin our power plants in our cells can't perform like they should and we are vulnerable to being ravaged by oxidative stress. Mitochondria are the major source of reactive oxygen species (ROS) as a byproduct of mitochondrial oxidative metabolism. Melatonin is one of the main compounds that mitochondria use to clear those ROS (free radicals).

Melatonin and its metabolites not only detoxifies reactive oxygen species, but it will also clear reactive nitrogen species. It also limits mitochondria-related apoptosis and maintains the efficiency of the respiratory chain complexes.

Melatonin could accurately be described as the premiere mitochondrial enhancer.

When our mitochondria are functioning optimally, tissue function where those mitochondria are located become optimal.

What happens when the pineal gland is removed?

Pinealectomy deprives animals of melatonin that are normally secreted by the pineal, but not from other organs. The results show that early pinealectomy accelerates the amount of oxidatively damaged products that accumulate throughout a lifetime and exaggerates membrane rigidity (Reiter, et al 1999).

As you can see, melatonin is much more than a sleep enhancer!

BENEFITS

  • Helps with insomnia and sleep disorders
  • Anti-inflammatory
  • Can act as an antioxidant
  • Helps protect the brain
  • Boost energy and fight stress

SUPPLEMENT FACTS

Other ingredients: hypromellose and water (capsule), bamboo extract. 

SUGGESTED USAGE

Take one or more capsules per day with or without a meal.

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Customer Reviews

Based on 7 reviews
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K
Kristen C (New York, US)
Relaxation

I ordered 50mg by mistake then I ordered the 5mg. One makes me feel totally relaxed and taking two kocks me out into a deep sleep. Best to take hour before bed and not too late.

C
Camille (Sonora, US)
Groggy

Definitely puts you to sleep but I'm curious why it makes me so groggy in the mornings. Can't take it everyday due to this.

M
M.P. (Port Huron, US)
Replaced my Benadryl dependence

I have struggled with severe insomnia since late 2019-early 2020. Due to what is believed to be stress, PTSD, and hormone issues. I have tried everything, had sleep studies done that showed I should have “no issues” and have 30+ bottles of sleep supplements varying from stand alone to combinations of melatonin, valerian, hopps, chamomile, lemon balm, plus more herbs. I have single bottles of certain herbs and combinations of combined herbs. I have tinctures, pills, capsules of varying doses and none of them have worked like the 50mg have. I had accepted that I would just have to depend on benedryl or even nyquil some nights just to sleep like a normal person. I was feeding my body enough protein and eating nourishing food through out the day and still struggling to sleep at all. I had given up hope and just accepted I could possibly develop early dementia from taking diphenhydramine every night as I felt I had no choice to be able to get up and go to work the next day. There were nights when even those stopped working and I would come to work running on 2 hours or sometimes no sleep at all just miserable. This product and the grounding sheet have been the best investments for my sleep. My quality of life is so much better, I don’t feel the anxiety and dread that I may not make it to work the next day due to not sleeping enough. I’m so thankful for this product.

J
Johnny Acevedo Jr (Atwater, US)
You will surely sleep alright.

This works, this helps with those insomniac like nights. Would like some more details on why I dream so much when I take them and yes they will make you groggy-ish depending on if you are getting the right amount of sleep, I'm not always groggy WHEN I take them, sometimes I'm fine maybe a little slower in the mornings but I guess you could say that you won't be waking up with anxiety like in a rush or hurry being anxious in the mornings as some may be. But yeah, a little more clarity on if these are side effects or is this too high of a dosage for myself. I don't want to be hurting myself through supplementing. Thank you kindly matt n mitolife been a member a couple years now, products are always great when I can afford, but for the most part haven't had any concerns or anything they work from my experiences.

C
Chanel (Calgary, CA)
Perfect Dose

It’s really difficult to find a melatonin in this dosage, but this one is perfect. I’ve built up to a higher dose over the last month or so and this is much easier than taking a million little 5mg pills.