MELATONIN - MITOCHONDRIAL SUPPORT
MELATONIN - MITOCHONDRIAL SUPPORT
Melatonin is one of the most misunderstood miracle compounds. Often called "the sleep hormone" it is lumped in with quick fixes and hormone therapy.
The reality is that melatonin is a master antioxidant and its beneficial effects extend far beyond sleep improvement. Before we dive into the details lets bust three myths that we often hear about melatonin.
Myth 1: Melatonin is mostly secreted by our pineal gland.
Actually, melatonin production by the pineal gland only accounts for 5% of total melatonin production. The majority, 95%, is produced by mitochondria in every cell throughout our body and is not regulated by dark-light circadian rhythm cycles.
Myth 2: Supplementing exogenous melatonin will lower our endogenous production.
The truth is the exact opposite. Taking exogenous melatonin has been shown to increase endogenous production. It does this by reactivating the pyruvate dehydrogenase complex to produce the necessary substrate acetyl Co-A for melatonin synthesis.
Myth 3: Melatonin is mostly a sleep hormone that regulates our circadian rhythm.
While melatonin does help regulate our circadian rhythm, it also scavenges free radicals, increases ATP production in the mitochondria, regulates glucose metabolism in every cell, regulates insulin secretion, maintains optimal mitochondria membrane potentials, modulates the immune system, and has an overall anti-aging effect on the body.
By 15–20 years of age we experience, on average, an 80% decline in melatonin levels and that decline continues into old age (Waldhauser, et al 1988). When we add to this bright light at night and electromagnetic radiation (EMR), we have a recipe for the lowest melatonin levels in human history. Could there be a connection to increased rates of disease?
What we're really talking about is mitochondrial integrity. Melatonin levels in mitochondria are about 100× higher than the levels found in the blood (Beaupre, et al 2021). Without sufficient melatonin our power plants in our cells can't perform like they should and we are vulnerable to being ravaged by oxidative stress. Mitochondria are the major source of reactive oxygen species (ROS) as a byproduct of mitochondrial oxidative metabolism. Melatonin is one of the main compounds that mitochondria use to clear those ROS (free radicals).
Melatonin and its metabolites not only detoxifies reactive oxygen species, but it will also clear reactive nitrogen species. It also limits mitochondria-related apoptosis and maintains the efficiency of the respiratory chain complexes.
Melatonin could accurately be described as the premiere mitochondrial enhancer.
When our mitochondria are functioning optimally, tissue function where those mitochondria are located become optimal.
What happens when the pineal gland is removed?
Pinealectomy deprives animals of melatonin that are normally secreted by the pineal, but not from other organs. The results show that early pinealectomy accelerates the amount of oxidatively damaged products that accumulate throughout a lifetime and exaggerates membrane rigidity (Reiter, et al 1999).
As you can see, melatonin is much more than a sleep enhancer!
Take one or more capsules per day with or without a meal.
This works, this helps with those insomniac like nights. Would like some more details on why I dream so much when I take them and yes they will make you groggy-ish depending on if you are getting the right amount of sleep, I'm not always groggy WHEN I take them, sometimes I'm fine maybe a little slower in the mornings but I guess you could say that you won't be waking up with anxiety like in a rush or hurry being anxious in the mornings as some may be. But yeah, a little more clarity on if these are side effects or is this too high of a dosage for myself. I don't want to be hurting myself through supplementing. Thank you kindly matt n mitolife been a member a couple years now, products are always great when I can afford, but for the most part haven't had any concerns or anything they work from my experiences.
It’s really difficult to find a melatonin in this dosage, but this one is perfect. I’ve built up to a higher dose over the last month or so and this is much easier than taking a million little 5mg pills.
I bought the 50mg, and boy is it strong. I take it at night about an hour before bed. Within 30 minutes, I can feel my self slipping into a relaxed state, and then falling asleep is not difficult at all. In fact, be careful of how strong this really is. I know Matt says Melatonin is beneficial not just for sleep, but I bought it specifically for sleep and it has not disappointed. My only complaint is that I do feel somewhat groggy in the morning, but that might change once I get used to taking it. Another hit from mitolife.
I started taking this Melatonin when it was first released, I don't quite know when to take the capsules. I have been taking them 30 minutes or so before bed, and it really knocks me out. It's so strong, I have been waking up REALLY groggy, which makes me wonder if there's a better time of day to take a capsule.