Probiotic & Endotoxin Reducer

  • This product is available.
    Unit price per 
Stock: 1778 left

Endotoxin, or lipopolysaccharide, is a molecule that's bound to intestinal bacteria. When they die, it is released. Under normal circumstances the liver and intestines can quickly eliminate it, but with polyunsaturated fat (PUFA) build-up in the liver and a lifetime of excessive fiber consumption, most people are compromised.

Low stomach acid, hypothyroidism (carbohydrate or animal protein restriction), stress, intermittent fasting, ketogenic diets, and stress all create a build-up of endotoxin.


You experiences allergies (food or environmental), autoimmune conditions, acne, eczema, rashes, constipation, diarrhea, acid reflux, infertility, menstrual dysfunction, irritable bowel disorder, diabetes, arthritis, migraines, edema, insomnia, poor sleep quality, energy dips, depression, anxiety, obsessive compulsive disorder, psychosis, the list goes on!


When the system is compromised and cannot eliminate endotoxin, it passes through the intestinal wall, enters circulation and spreads throughout the entire system. Endotoxin itself increases intestinal permeability. Glyphosate is just a small piece of the puzzle! Got stress? Restricting carbohydrate or animal protein? Low HCL?


The primary mechanism that we use to detoxify stored PUFAs from the liver is called glucuronidation, and this process is inhibited by endotoxin (Bánhegyi, et al, 1995).

Ulcerative colitis (UC) and Crohn's disease (CD) [inflammatory bowel disease (IBD) all have endotoxin in common (Caradonna, et al., 2000).

Endotoxin increases liver and organ damage from alcohol (Purohit, et al., 2008). 

Circulating lipopolysaccharide significantly increased in chronically HIV-infected individuals (Brenchley, et al., 2006). 

Endotoxin suppresses the thyroid gland, the immune system and leads to an increase in nitric oxide and the stress hormones estrogen, serotonin and prolactin, which further increase endotoxin production.


"Spore based" is just another way of saying "Soil based". They are microorganisms that are formed from spores. You can get these same strains in the dirt or on vegetables with dirt residue. They are just concentrated in this supplement and you know exactly what you're getting.

A study conducted by the World Journal of Gastrointestinal Pathophysiology found that just 30 (thirty!) days of spore-based probiotic oral supplementation reduced endotoxin by 42% (Mcfarlin, et al., 2017). They also saw a 24% reduction in triglycerides and a decrease in systemic inflammation markers. The subjects took two capsules a day.

They used five strains including Bacillus clausii, Bacillus subtilis, Bacillus coagulans, the strains included in the Mitolife Probiotic. We chose to omit the carotenoid-producing strain as carotenoids have been demonstrated to suppress thyroid function if they accumulate in the tissues. 

Bacillus bacteria are gram-positive instead of the endotoxin producing gram-negative bacteria. They can be found in animal guts, air, water and soil. They have the ability to make various antimicrobial and antibiotic-like compounds (Elshaghabee, et al., 2017). They also have immuno-modulatory and anti-mutagenic effects.  

Like minerals, there are a lot of them, but only a handful make a difference.

Bacillus subtilis has even been studied as a prevention for diabetes. The researchers found that it protected the beta cells of the pancreas, leading to decreased blood glucose levels (Zouari, et al., 2015). 


The formula also contains a small amount of Fructooligosaccharides. This compound occurs naturally in plants and consists of a string of fructose units. They are very safe and stimulate the growth of nonpathogenic gut bacteria.


You can take one capsule with breakfast and one at night with dinner. They can also be taken on an empty stomach. Time of day when you take them doesn't matter. 

Supporting your metabolism with food frequency and balanced meals helps to reduce endotoxin buildup. Do not restrict sugar (carbohydrates) or animal protein. Let's get those endotoxin levels down! 


Probiotic Blend - 5 Billion CFU, Bacillus coagulans, Bacillus subtilis, Bacillus clausii, Prebiotic, FOS (Fructooligosaccharides) 

 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.

Customer Reviews

Based on 28 reviews
Rebecca Bergan (New Braunfels, US)
Great for Bacteria Die Off When On Antibiotics

I came down fairly ill this past summer with heart related issues, tachycardia and palpitations. Of course my case was a mystery to doctors and it turns out my gut has been over run by 'Klebsiella Pneumoniae' (the bacteria that causes pneumonia).

With a gut biome so messed up that I practically don't have any living probiotics and an over abundance of bad bacteria, the endotoxin load on my body is very high. I didn't really realize it until I quit taking my spore probiotic one week and my symptoms that had mostly left came back! What misery! Once I started back on it the symptoms went away again after a few days.

Now I can take these any time my heart rate elevates and it will subside. It also has been a life saver on those days when I have no appetite and just the thought of food makes me nauseous. Any one following the information Matt Blackburn shares would know that in that scenario not eating is just going to make the nausea worse, so I try my best to eat to no avail. But, I have realized that taking one of these endotoxin reducers will make my appetite return within just 20-60 minutes! I know the importance of food in anyone's recovery journey so this has been a big help to keep me eating!

Now I take 1-4 daily. 1 as a minimum each day and 1 whenever my symptoms flare up. I recently started an herbal-antibiotic protocol to kill the Klebsiella and this Probiotic and Endotoxin Remover is helping me to cope with the bacteria die off.

I'm a fairly small woman so 1 capsule at a time does wonders for me.

Basie Espinoza (Montclair, US)
Endotoxin Reducer

When recovering from XYZ this should be in your regime, when I have added Mitolifes spore based probiotics and other Mitolifes products, my skin condition has cleared up and many of my enzymes are coming back online. I stand behind Mitolifes products because it produces results, for my skin condition to improve it took 3-4 days and I can’t wait to see what other benefits I will experience.

Stephen Waddell (Quinton, US)
Significantly helpful

Since starting this probiotic(about 2weeks so far), I have notice the slight brain fog being lifted. I’m excited to continue to these supplements and being brought closer to equilibrium. I’m really enjoying having more broad understanding via Matt’s work and experience that helps with knowing which supplements are needed, and for What! So many things being pushed in mainstream that actually doesn’t do anything but take a system more Out of balance. I’m grateful for Matt’s sharing of what he knows through trail and error, it’s already brought clarity and after a significant head injury back in 2001, being fully invested to turning thing around since 2007, feel like I’ve finally found something in these products that are actually starting to lift the remaining systemic issues that have been at play for so long.
This rocks! Can’t wait to stock up on the dissolve it all, too!!!

Thanks Matt and crew!

Sara T (Chula Vista, US)
Love this product

I absolutely love this product! I’ve had gut issues my whole life and have tried many products. Having Hasimoto’s and a sluggish metabolism, and I’m sure lots of endotoxins…I had learned to live with a lower bar of expectations for my gut health.
I finally quit smoking 6 months ago, and I didn’t have any lung issues- but I had the worst nausea, constipation, and indigestion imaginable. I tried everything:: store bought enzymes, probiotics, laxatives - nothing worked until I started using this product. Total game changer!

Mychel (Honolulu, US)
Underwhelmed by product

Again I have been taking these for almost two weeks now and don't feel any difference. No negative or positive effects at all. I'm kind of disappointed because I take shilajit and absolutely feel the difference it makes. I was hoping for the same results from these probiotics but no such luck. I will up my daily dosage in a few days and take till I run out of this bottle as well since I don't seem to be experiencing any negative side effects. Hopefully I will feel some positive effects with a higher dose. If not I will not purchase this again.