Probiotic & Endotoxin Reducer

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Endotoxin, or lipopolysaccharide, is a molecule that's bound to intestinal bacteria. When they die, it is released. Under normal circumstances the liver and intestines can quickly eliminate it, but with polyunsaturated fat (PUFA) build-up in the liver and a lifetime of excessive fiber consumption, most people are compromised.

Low stomach acid, hypothyroidism (carbohydrate or animal protein restriction), stress, intermittent fasting, ketogenic diets, and stress all create a build-up of endotoxin.


You experiences allergies (food or environmental), autoimmune conditions, acne, eczema, rashes, constipation, diarrhea, acid reflux, infertility, menstrual dysfunction, irritable bowel disorder, diabetes, arthritis, migraines, edema, insomnia, poor sleep quality, energy dips, depression, anxiety, obsessive compulsive disorder, psychosis, the list goes on!


When the system is compromised and cannot eliminate endotoxin, it passes through the intestinal wall, enters circulation and spreads throughout the entire system. Endotoxin itself increases intestinal permeability. Glyphosate is just a small piece of the puzzle! Got stress? Restricting carbohydrate or animal protein? Low HCL?


The primary mechanism that we use to detoxify stored PUFAs from the liver is called glucuronidation, and this process is inhibited by endotoxin (Bánhegyi, et al, 1995).

Ulcerative colitis (UC) and Crohn's disease (CD) [inflammatory bowel disease (IBD) all have endotoxin in common (Caradonna, et al., 2000).

Endotoxin increases liver and organ damage from alcohol (Purohit, et al., 2008). 

Circulating lipopolysaccharide significantly increased in chronically HIV-infected individuals (Brenchley, et al., 2006). 

Endotoxin suppresses the thyroid gland, the immune system and leads to an increase in nitric oxide and the stress hormones estrogen, serotonin and prolactin, which further increase endotoxin production.


"Spore based" is just another way of saying "Soil based". They are microorganisms that are formed from spores. You can get these same strains in the dirt or on vegetables with dirt residue. They are just concentrated in this supplement and you know exactly what you're getting.

A study conducted by the World Journal of Gastrointestinal Pathophysiology found that just 30 (thirty!) days of spore-based probiotic oral supplementation reduced endotoxin by 42% (Mcfarlin, et al., 2017). They also saw a 24% reduction in triglycerides and a decrease in systemic inflammation markers. The subjects took two capsules a day.

They used five strains including Bacillus clausii, Bacillus subtilis, Bacillus coagulans, the strains included in the Mitolife Probiotic. We chose to omit the carotenoid-producing strain as carotenoids have been demonstrated to suppress thyroid function if they accumulate in the tissues. 

Bacillus bacteria are gram-positive instead of the endotoxin producing gram-negative bacteria. They can be found in animal guts, air, water and soil. They have the ability to make various antimicrobial and antibiotic-like compounds (Elshaghabee, et al., 2017). They also have immuno-modulatory and anti-mutagenic effects.  

Like minerals, there are a lot of them, but only a handful make a difference.

Bacillus subtilis has even been studied as a prevention for diabetes. The researchers found that it protected the beta cells of the pancreas, leading to decreased blood glucose levels (Zouari, et al., 2015). 


The formula also contains a small amount of Fructooligosaccharides. This compound occurs naturally in plants and consists of a string of fructose units. They are very safe and stimulate the growth of nonpathogenic gut bacteria.


You can take one capsule with breakfast and one at night with dinner. They can also be taken on an empty stomach. Time of day when you take them doesn't matter. 

Supporting your metabolism with food frequency and balanced meals helps to reduce endotoxin buildup. Do not restrict sugar (carbohydrates) or animal protein. Let's get those endotoxin levels down! 


Probiotic Blend - 5 Billion CFU, Bacillus coagulans, Bacillus subtilis, Bacillus clausii, Prebiotic, FOS (Fructooligosaccharides) 

 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.

Customer Reviews

Based on 59 reviews
Laura Fisher (Annandale, US)

best probiotic I’ve ever taken! Felt a difference right away!!!!

Dorin (Westland, US)
Straight To Business Product

This is powerful stuff. Based on where my gut is I have to cut the portion down to 1/3 capsules. I just have to purchase empty capsules from Amazon. But we mus all adjust to our body’s growth and learn how to help it push itself to equilibrium.

Samantha Rolnick (The Bronx, US)

Not sure how many bottles I’ve gotten of this, but taking this probiotic is just as important as breathing, to me. I had a chronic stomach ache for 26 years (I’m now 28) due to being born with a damaged gut micro biome and leaky gut. I had never been able to tolerate food of any kind. This probiotic simply changed my life. I can hold a job, eat semi normally. Truly a game changer for me and I won’t ever go back to anything else.

Allyssa Leach (Vernon, CA)
Good stuff 👍

I've been taking beef liver, vit E, mag for months while on my healing journey (Thyroid, reoccurring UTIs) since having my 2nd son. I recently added mito life's probiotic about 5 or 6 weeks ago.. this was huge for my healing journey! I've noticed the biggest difference all around with adding this probiotic in. Highly recommend & will be ordering my 2nd bottle.

C. (Red Lion, US)
already less bloating

I’ve struggled with unexplained bloating on and off (more on than off) since about 2016 - which I *think* started after a round of antibiotics I had to take for cellulitis that developed as a result of a spider bite. I’ve been to a GI specialist, had internal biopsies, and still no concrete answers. I’ve tried more than a handful of different probiotics and I never noticed a bit of difference (other than stomach upset) until I tried this. I’m not 100% ‘back to normal’ but I’m also not even the whole way through a bottle. What I can say is that I have tolerated a single pill a day very well, zero stomach upset, and have woken up in the morning with a nearly flat stomach multiple times since starting this — that hasn’t happened in nearly 7 years, so I’ll take the win. I’ll be finishing this bottle and will likely be ordering more. Thank you Matt!